Preclinical Modeling

Traumatic injuries resulting from ischemic damage, nerve transection injuries, or volumetric defects in bone and soft tissues are an intractable problem. Surgical reconstruction can lead to extensive morbidity, muscle fibrosis and diminished limb function owing to chronic muscle strength deficits. Even minor damage and or overuse of supporting connective tissues such as the rotator cuff tendon, and associated mechanical unloading, results in disorganized tissue remodeling, gradual fatty/fibrous degeneration and strength deficits. And, as the sequelae of traumatic injuries increase at a disproportionate rate with advancing age, the burden of musculoskeletal injury to our aging population is increasingly severe. Our lab develops experimental models of musculoskeletal injury in order to develop newer, more highly effective treatments. For the latest insights into treatments that harness innate immune responses, please check out our recent review paper.

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