See Our Latest Publication Stem Cells

Hematopoietic stem and progenitor cells (HSPCs) egress from bone marrow (BM) during homeostasis and at incrased rates during stress; however, the mechanisms regulating their trafficking remain incompletely understood. Here we describe a novel role for lipid receptor, sphingosine-1-phosphate receptor 3 (S1PR3), in HSPC residence within the BM niche. HSPCs more …