An additional interest is the development of “immunologically smart” biomaterials that can tune the regenerative potential of subpopulations of leukocytes to the needs defined by the injury microenvironment. Our goal is to harness the phenotypic complexity and the division of labor among innate immune cell subsets to amplify endogenous mechanisms of tissue repair. In one recent example, we have shown that diverting circulating non-classical monocytes to injury sites using extracellular matrix (ECM)-derived hydrogels promotes healing and inflammation resolution in musculoskeletal injuries. Read More