Jada Selma

Jada Selma completed her undergraduate degree in biomedical engineering at Mississippi State University in Starkville, MS. She joined Dr. Botchwey’s lab in 2012. Jada’s work focuses on elucidating the underlying cellular and molecular mechanisms behind pathological bone remodeling in sickle cell disease (SCD).  Previous transgenic sickle mouse model studies have shown that increased osteoclast activity and reduced mesenchymal stem cell (MSC) differentiation into osteoblasts contributes broadly to sickle bone disease (SBD). However, Jada’s project aims to link SBD to the finding that sphingolipid metabolism is dysregulated in SCD.  Sphingosine 1-phosphate (S1P), a type of sphingolipid that is upregulated in SCD, directs a wide array of cellular processes including, migration, cell-cell adhesion, survival, and proliferation. S1P has also been found to direct MSCs towards an osteogenic lineage and modulates their migration. Moreover, Jada is also investigating the role of cell-derived microparticle  internalization by osteoclastic precursors in contributing to pathologic bone resorption in SCD due to increased inflammation and proteolytic activity.   In ongoing collaborative work, Jada is interested in applying these concepts to determine potential therapeutic targets for SBD as well as to improve MSC therapy for other bone disorders