We are using high-through-put lipid chromatography and mass spectrometry (LC-MS) analysis to investigate membrane metabolism and signaling through sphingolipids. We use sickle red blood cells and adult stem cells as model systems to gain insight into disease pathology and therapeutic cell potency respectively. We believe that our integrated systems-based research approach can compliment existing knowledge bases linking sphingolipids to wife range of biological processed, including cell death mechanisms, formation of inflammatory membrane microparticles, and secretion of soluble signals. For broader discussion of our interests in systems based approaches to understand pathogenic mechanisms and to find ways to induce pro-regenerative signaling, see our previous review paper.
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