See Our Scientific Reports Paper

Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of in ammation and healing outcome. Immunoregenerative materials leverage the function of endogenous immune cells to orchestrate complex mechanisms of repair; however, a deeper understanding of innate immune cell function in in amed tissues and their subsequent interactions with implanted materials is necessary to guide the design … [more]

See Our Latest Publication in Acta Biomaterialia

Omega-3 polyunsaturated fatty acid-derived resolvins are gaining increasing recognition for their essential roles in inhibition of neutrophil invasion into inflamed tissue and promotion of macrophage phagocytosis of cellular debris as well as their egress to the lymphatics. Biomaterial-based release of lipid mediators is a largely under-explored approach more …

See Our Latest Publication Stem Cells

Hematopoietic stem and progenitor cells (HSPCs) egress from bone marrow (BM) during homeostasis and at incrased rates during stress; however, the mechanisms regulating their trafficking remain incompletely understood. Here we describe a novel role for lipid receptor, sphingosine-1-phosphate receptor 3 (S1PR3), in HSPC residence within the BM niche. HSPCs more …

Edward Botchwey, Ph.D. elected to AIMBE College of Fellows

The American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Dr. Edward Botchwey to its College of Fellows  for outstanding contributions to immunoregulatory biomaterials and national leadership in biomedical engineering. Each year, fellows are nominated by their peers in the medical and biological engineering community, and a select few are chosen to represent the “life-blood of AIMBE’s vision to provide medical and biological engineering innovation for the benefit of humanity.” The AIMBE College of Fellows recognizes  the top 2% of outstanding bioengineers in academia, industry and government.


Dr. Botchwey on Monocytes

Therapeutic Angiogenesis and Bone Regeneration with Natural and Synthetic Small Molecules