Entries by blabadmin

See Our Latest Publication in Science Advances Focused on Specialized Pro-Angiogenic Neutrophils

To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional subsets along a pseudotime trajectory and identify distinct VEGFR1, VEGFR2, and CXCR4 high-expressing […]

Publication in JBMRA on Modulating S1P Receptor Signaling as a Regenerative Immunotherapy

Regeneration of skeletal muscle after volumetric injury is thought to be impaired by a dysregulated immune microenvironment that hinders endogenous repair mechanisms. Such defects result in fatty infiltration, tissue scarring, chronic inflammation, and debilitating functional deficits. Here, we evaluated the key cellular processes driving dysregulation in the injury niche through localized modulation of sphingosine‐1‐phosphate (S1P) […]

Check Out Our Latest Publication in Biomaterials

Inflammation after traumatic injury or surgical intervention is both a protective tissue response leading to regeneration and a potential cause of wound complications. One potentially successful strategy to harness to pro-regenerative roles of host inflammation is the localized delivery of bioactive materials to induce immune suppressive cellular responses by cells responding to injury. In this […]

S’Dravious DeVeaux

S’Dravious “Dré” DeVeaux graduated from Georgia Southern University with a BS in Chemistry with a concentration in Biochemistry and minors in Biology and Mathematics in Fall 2015. Upon graduation he worked full-time as a Purification Chemist I before matriculating to Univeristy of Georgia (UGA) in Fall 2016. He graduate from UGA with his Masters in […]

Edward Botchwey Wins 2019 Mid-Career Award from the Society For Biomaterials

Award recognizes outstanding achievements in the field of biomaterials research Edward Botchwey, associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, received the 2019 Mid-Career Award from the Society For Biomaterials (SFB). This prestigious award is specifically given to recognize an individual who has demonstrated outstanding achievements […]

Single Cell Analysis of Inflammation

Understanding cellular heterogeneity in response to an injury,biomaterial implantation and/or drug delivery is instrumental to developing a successful regenerative medicine treatment. Therefore, we regularly take advantage of techniques such as high dimensional flow cytometry and particle tracking using confocal microscopy to fully capture such responses.   As single cell analytical techniques evolve the ability to […]

CELL CHARACTERIZATION AND MANUFACTURING

We aim to develop new technologies to enhance the therapeutic potency of cell-based therapies. With support from the Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M) we are utilizing high performance liquid chromatography-mass spectrometry (HPLC-MS/MS) to characterize the anti-inflammatory potential of mesenchymal stem cell (MSCs) based on metabolism of membrane sphingolipid (SLs). We use multi-variate analysis of lipidomic network profiles and cutting imaging analysis methods to […]

Cheryl San Emeterio, Ph.D.

Cheryl San Emeterio completed her undergraduate degree in biomedical engineering at Vanderbilt University. She joined Dr. Botchwey’s lab at Georgia Tech in 2012. Cheryl’s work focuses on engineering immunomodulatory biomaterials that harness pro-regenerative myeloid cell behavior during soft tissue injury. Cheryl’s recently published work demonstrates that blood-derived non-classical monocytes are biased progenitors of wound-healing macrophages within traumatic skin […]