Entries by blabadmin

See Our Scientific Reports Paper

Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of in ammation and healing outcome. Immunoregenerative materials leverage the function of endogenous immune cells to orchestrate complex mechanisms of repair; however, a deeper understanding of innate immune cell function in in amed tissues and their subsequent […]

See Our Latest Publication in Acta Biomaterialia

Omega-3 polyunsaturated fatty acid-derived resolvins are gaining increasing recognition for their essential roles in inhibition of neutrophil invasion into inflamed tissue and promotion of macrophage phagocytosis of cellular debris as well as their egress to the lymphatics. Biomaterial-based release of lipid mediators is a largely under-explored approach more …

See Our Latest Publication Stem Cells

Hematopoietic stem and progenitor cells (HSPCs) egress from bone marrow (BM) during homeostasis and at incrased rates during stress; however, the mechanisms regulating their trafficking remain incompletely understood. Here we describe a novel role for lipid receptor, sphingosine-1-phosphate receptor 3 (S1PR3), in HSPC residence within the BM niche. HSPCs more …

Edward Botchwey, Ph.D. elected to AIMBE College of Fellows

The American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Dr. Edward Botchwey to its College of Fellows  for outstanding contributions to immunoregulatory biomaterials and national leadership in biomedical engineering. Each year, fellows are nominated by their peers in the medical and biological engineering community, and a select few are […]

METABOLOMICS AND PATHOBIOLOGY

We have devoted significant attention in recent years to the role of sphingolipid metabolism in sickle red blood cells. We have recently identified a novel mechanism of feed-forward inflammatory signaling in SCD whereby sickled RBC membrane strain increases the activity of sphingomyelinase (SMase), which contributes to membrane lipid composition and budding of cellular vesicles. This […]

SMART BIOMATERIALS

An additional interest is the development of “immunologically smart” biomaterials that can tune the regenerative potential of subpopulations of leukocytes to the needs defined by the injury microenvironment. Our goal is to harness the phenotypic complexity and the division of labor among innate immune cell subsets to amplify endogenous mechanisms of tissue repair. In one […]

ENDOGENOUS TISSUE ENGINEERING

Our interest is to understand the microenvironmental factors that govern healing outcomes in musculoskeletal tissues and skin in order to harness endogenous mechanisms of repair. Efficient wound healing requires the angiogenic and fibrogenic activity of macrophages, which are derived at least in part from circulating monocytes that undergo differentiation post-extravasation. We focus specifically on unlocking […]

Intravital Imaging

We have extensively utilized the dorsal skinfold window chamber model (a.k.a. “backpack”) for development of appropriate biomaterial-based biomolecular delivery strategies for targeted recruitment of MP populations and for assessing their contributions to microvascular growth and remodeling. This chronic window chamber model permits both systemic and localized in vivo assessment of dynamic interactions of engineered materials […]